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Optical coherence tomografiya angiografiya (OCTA) nuburyo bushya bwo kutabona amashusho yimitsi itagaragara.Nubwo OCTA ifite ibyifuzo byinshi byubuvuzi, kumenya ubwiza bwibishusho bikomeje kuba ingorabahizi.Twateje imbere uburyo bwimbitse bwo kwiga dukoresheje ResNet152 imiyoboro y'urusobe rwerekanwe na ImageNet kugirango dushyire ahagaragara amashusho ya capillary plexus ya superficial kuva 347 scan yabarwayi 134.Amashusho kandi yasuzumwe nintoki nkukuri kwukuri nabashakashatsi babiri bigenga kuburyo bwo kwiga bugenzurwa.Kuberako ibisabwa byujuje ubuziranenge bishobora gutandukana bitewe nubuvuzi cyangwa ubushakashatsi, imiterere ibiri yarahuguwe, imwe yo kumenyekanisha amashusho meza kandi indi yo kumenyekanisha ubuziranenge.Urusobe rwacu rwimitsi rwerekana ahantu heza munsi yumurongo (AUC), 95% CI 0.96-0.99, \ (\ kappa \) = 0.81), bikaba byiza cyane kurwego rwibimenyetso byatangajwe na mashini (AUC = 0.82, 95 % CI).0.77–0.86, \ (\ kappa \) = 0.52 na AUC = 0,78, 95% CI 0.73–0.83, \ (\ kappa \) = 0.27, uko bikurikirana).Ubushakashatsi bwacu bwerekana ko uburyo bwo kwiga imashini bushobora gukoreshwa mugutezimbere uburyo bworoshye kandi bukomeye bwo kugenzura amashusho ya OCTA.
Optical coherence tomografiya angiografiya (OCTA) nubuhanga bushya bushingiye kuri optique coherence tomografiya (OCT) ishobora gukoreshwa muburyo butagaragara bwo kubona amashusho ya microcasculature.OCTA ipima itandukaniro muburyo bwo gutekereza uhereye kumatara yumucyo asubirwamo mugace kamwe ka retina, hanyuma kwiyubaka birashobora kubarwa kugirango bigaragaze imiyoboro y'amaraso idakoresheje amarangi cyangwa irangi ritandukanye.OCTA ituma kandi imiterere-y-imashusho yimbitse-yerekana imitsi, ituma abaganga basuzuma bitandukanye ibice byimbere kandi byimbitse, bifasha gutandukanya indwara ya chorioretinal.
Nubwo ubu buhanga butanga ikizere, itandukaniro ryubwiza bwibishusho rikomeje kuba ingorabahizi yo gusesengura amashusho yizewe, bigatuma gusobanura amashusho bigorana no gukumira kwivuza kwinshi.Kuberako OCTA ikoresha scan nyinshi zikurikirana OCT, irumva cyane ibihangano byamashusho kuruta OCT isanzwe.Ibicuruzwa byinshi byubucuruzi OCTA bitanga ishusho yubuziranenge bwibipimo byitwa Signal Strength (SS) cyangwa rimwe na rimwe ibimenyetso byerekana imbaraga (SSI).Nyamara, amashusho afite agaciro gakomeye SS cyangwa SSI ntabwo yemeza ko hatabayeho ibihangano byamashusho, bishobora kugira ingaruka kubisesengura ryamashusho hanyuma biganisha kumyanzuro mibi yubuvuzi.Ibikoresho bisanzwe byamashusho bishobora kugaragara mumashusho ya OCTA harimo ibihangano byerekanwe, ibihangano byigice, ibihangano bya opacite ibihangano, hamwe nibikorwa bya projection1,2,3.
Nkuko ingamba zikomoka kuri OCTA nkubucucike bwamaraso zigenda zikoreshwa mubushakashatsi bwubuhinduzi, ibizamini byamavuriro hamwe nubuvuzi, hakenewe byihutirwa guteza imbere uburyo bukomeye kandi bwizewe bwo kugenzura ubuziranenge bwibishusho kugirango bikureho ibihangano4.Gusimbuka guhuza, bizwi kandi nkibisigisigi bisigaye, ni ibishushanyo mbonera byubwubatsi bwurusobe rwemerera amakuru kurenga ibice byemeza mugihe ubika amakuru kumunzani cyangwa imyanzuro5.Kuberako ibihangano byamashusho bishobora kugira ingaruka nto-nini muri rusange nini-nini-nini-shusho-mikorere, gusimbuka-imiyoboro ihuza imiyoboro ikwiranye no gutangiza iki gikorwa cyo kugenzura ubuziranenge5.Ibikorwa biherutse gusohoka byerekanye amasezerano amwe mumiyoboro yimbitse yimitekerereze yatojwe hakoreshejwe amakuru meza yo mubigereranyo byabantu6.
Muri ubu bushakashatsi, turahugura guhuza-gusimbuka imitekerereze ya neural net kugirango duhite tumenya ubwiza bwamashusho ya OCTA.Twubaka kubikorwa byabanje dutezimbere uburyo butandukanye bwo kumenya amashusho meza kandi yerekana amashusho meza, kuko ibisabwa byujuje ubuziranenge bishobora gutandukana kubintu byihariye byubuvuzi cyangwa ubushakashatsi.Turagereranya ibisubizo byiyi miyoboro hamwe numuyoboro uhuza imitekerereze udafite aho uhurira kugirango dusuzume agaciro ko gushyiramo ibintu murwego rwinshi rwa granularité mu myigire yimbitse.Hanyuma twagereranije ibisubizo byacu kugirango twerekane imbaraga, igipimo cyemewe cyemewe cyubwiza bwibishusho butangwa nababikora.
Mu bushakashatsi bwacu harimo abarwayi barwaye diyabete bitabiriye ikigo cya Yale Eye Centre hagati ya 11 Kanama 2017 na 11 Mata 2019. Abarwayi bafite indwara ya chorioretinal itari diyabete barahawe akato.Nta ngingo ngenderwaho zo gushyiramo cyangwa guhezwa zishingiye ku myaka, igitsina, ubwoko, ubwiza bw'ishusho, cyangwa ikindi kintu icyo ari cyo cyose.
Amashusho ya OCTA yabonetse hakoreshejwe urubuga rwa AngioPlex kuri Cirrus HD-OCT 5000 (Carl Zeiss Meditec Inc, Dublin, CA) munsi ya 8 \ (\ inshuro \) 8 mm na 6 \ (\ inshuro \) 6 mm yerekana amashusho.Icyemezo kibimenyeshejwe cyo kugira uruhare muri ubwo bushakashatsi cyabonetse kuri buri wese mu bitabiriye kwiga, kandi Ikigo gishinzwe isuzuma ry’ibigo bya kaminuza ya Yale (IRB) cyemeje gukoresha uruhushya rumenyeshwa n’ifoto ku isi kuri aba barwayi bose.Gukurikiza amahame y'Itangazo rya Helsinki.Ubushakashatsi bwemejwe na kaminuza ya Yale IRB.
Amashusho yerekana isahani yasuzumwe hashingiwe ku manota yavuzwe mbere ya Motion Artifact Score (MAS), amanota yavuzwe mbere ya Segmentation Artifact Score (SAS), ikigo cya foveal, kuba itangazamakuru ridahwitse, hamwe no kubona amashusho meza ya capillaries nkuko byagenwe nuwashinzwe gusuzuma amashusho.Amashusho yasesenguwe nabashakashatsi babiri bigenga (RD na JW).Ishusho ifite amanota 2 (yujuje ibisabwa) niba ibisabwa byose bikurikira byujujwe: ishusho yibanze kuri fovea (munsi ya pigiseli 100 kuva hagati yishusho), MAS ni 1 cyangwa 2, SAS ni 1, na itangazamakuru ridahwitse riri munsi ya 1. Kugaragaza kumashusho yubunini / 16, kandi capillaries nto igaragara mumashusho arenze 15/16.Ishusho irapimwe 0 (nta gipimo) niba hari kimwe mubipimo bikurikira byujujwe: ishusho iri hagati, niba MAS ari 4, niba SAS ari 2, cyangwa impuzandengo irenze 1/4 cyishusho, kandi capillaries nto ntishobora guhindurwa kurenza 1 shusho / 4 kugirango itandukanye.Andi mashusho yose atujuje ibipimo 0 cyangwa 2 byatsinzwe nka 1 (gukata).
Ku mutini.1 yerekana amashusho yintangarugero kuri buri gipimo cyagereranijwe hamwe nibishusho.Inter-rater kwizerwa kumanota kugiti cye yasuzumwe nuburemere bwa kappa ya Cohen8.Amanota kugiti cya buri cyiciro cyegeranijwe kugirango abone amanota rusange kuri buri shusho, kuva kuri 0 kugeza kuri 4. Amashusho afite amanota 4 yose afatwa nkibyiza.Amashusho afite amanota 0 cyangwa 1 afatwa nkubuziranenge.
Umuyoboro wa ResNet152 wububiko bwa neural neural (Igishusho 3A.i) wabanje gutozwa kumashusho avuye mububiko bwa ImageNet wakozwe ukoresheje fast.ai hamwe na PyTorch framework5, 9, 10, 11. Umuyoboro uhuza imitsi ni umuyoboro ukoresha abize muyunguruzi yo gusikana amashusho ibice kugirango wige ahantu hamwe nibiranga.ResNet yacu yatojwe ni umuyoboro wa 152-urwego rwimitsi irangwa nicyuho cyangwa "amasigarira asigaye" yohereza icyarimwe amakuru hamwe nibyemezo byinshi.Mugushushanya amakuru kumyanzuro itandukanye kurusobe, urubuga rushobora kwiga ibiranga amashusho yujuje ubuziranenge kurwego rwinshi.Usibye icyitegererezo cya ResNet, twatoje kandi AlexNet, yize neza imyubakire y'urusobe rw'imitsi, nta kubura guhuza kugereranya (Ishusho 3A.ii) 12.Hatabuze guhuza, uyu muyoboro ntushobora gufata ibintu murwego rwo hejuru.
Umwimerere 8 \ (\ inshuro \) 8mm OCTA13 ishusho yashizweho yazamuwe hakoreshejwe tekinoroji yo gutambuka no guhagarikwa.Dataset yuzuye noneho yagabanijwe kubushake kurwego rwamashusho mumahugurwa (51.2%), kugerageza (12.8%), hyperparameter tuning (16%), no kwemeza (20%) datasets ukoresheje scikit-yiga agasanduku k'ibikoresho python14.Imanza ebyiri zarasuzumwe, imwe ishingiye ku kumenya gusa amashusho yo mu rwego rwo hejuru (amanota rusange 4) naho indi ishingiye ku kumenya amashusho yo hasi gusa (amanota 0 cyangwa 1).Kuri buri kintu cyiza kandi cyiza cyo gukoresha, urusobe rw'imitsi rusubirwamo rimwe kumakuru yacu.Muri buri kibazo cyo gukoresha, urusobe rw'imitsi rwahuguwe mu bihe 10, byose usibye uburemere bwo hejuru cyane byarahagaritswe, kandi uburemere bwibipimo byose byimbere byigishijwe ibihe 40 hakoreshejwe uburyo bwo kwiga ivangura hamwe nigikorwa cyo gutakaza cross-entropy 15, 16..Igikorwa cyo gutakaza umusaraba entropy nigipimo cya logarithmic igipimo cyo kunyuranya hagati yibirango byateganijwe hamwe namakuru nyayo.Mugihe cyamahugurwa, kumanuka gahoro gahoro bikorwa kumurongo wimbere wurusobe rwimitsi kugirango ugabanye igihombo.Igipimo cyo kwiga, igipimo cyo guta ishuri, hamwe no kugabanya ibiro hyperparameter byateguwe hifashishijwe uburyo bwiza bwa Bayesian hamwe nibintu 2 byatangiriye gutangirira hamwe 10, kandi AUC kuri dataset yahujwe hakoreshejwe hyperparameter nkintego ya 17.
Ingero zerekana za 8 × 8 mm OCTA amashusho ya capillary plexus superficial yatsinze amanota 2 (A, B), 1 (C, D), na 0 (E, F).Ibishusho byerekanwe birimo imirongo ihindagurika (imyambi), ibihangano byo gutandukanya (inyenyeri), hamwe nibitangazamakuru (imyambi).Ishusho (E) nayo iri hagati.
Imikorere yakira ibiranga (ROC) umurongo noneho bigakorwa kubintu byose byurusobe rwimitsi, kandi raporo yerekana imbaraga za moteri zitangwa kuri buri kintu cyiza kandi cyiza cyo gukoresha.Agace kari munsi yu murongo (AUC) kabaruwe hifashishijwe pROC R, kandi 95% intera yicyizere na p-gaciro byabazwe hakoreshejwe uburyo bwa DeLong 18,19.Amanota yo guteranya amanota yabantu akoreshwa nkibanze kumibare yose ya ROC.Ku mbaraga zerekana ibimenyetso byatangajwe na mashini, AUC yabazwe kabiri: rimwe kubiranga ubuziranenge bwo hejuru Scalability Score na rimwe kubiciro byo hasi ya Scalability Score.Urusobe rw'imitsi igereranwa n'imbaraga za AUC zerekana imyitozo yacyo hamwe nisuzuma ryayo.
Kugirango turusheho kugerageza icyitegererezo cyimbitse cyahuguwe kuri dataset zitandukanye, ubuziranenge bwo hejuru kandi bufite ubuziranenge bwakoreshejwe muburyo butaziguye bwo gusuzuma imikorere ya 32 yuzuye isura 6 \ (\ inshuro \) 6mm yerekana amashusho yakusanyirijwe muri kaminuza ya Yale.Amaso y'ijisho yibanze mugihe kimwe nishusho 8 \ (\ inshuro \) 8 mm.Amashusho ya 6 \ (\ × \) 6 mm yasuzumwe nintoki nabapimwe (RD na JW) muburyo bumwe na 8 \ (\ × \) 8 mm 8, AUC yabazwe kimwe nukuri hamwe na kappa ya Cohen .kimwe.
Ikigereranyo cyo kutaringaniza ibyiciro ni 158: 189 (\ (\ rho = 1.19 \)) kubwicyitegererezo cyiza na 80: 267 (\ (\ rho = 3.3 \)) kubwicyitegererezo cyiza.Kuberako igipimo cyo kutaringaniza ibyiciro kiri munsi ya 1: 4, ntamahinduka yihariye yubatswe yakozwe kugirango akosore ubusumbane bwibyiciro20,21.
Kugirango urusheho kwiyumvisha neza uburyo bwo kwiga, amakarita yo gutangiza ibyiciro yakozwe kubwuburyo bune bwatojwe bwimbitse: icyitegererezo cyiza cya ResNet152, icyitegererezo cyiza cya ResNet152, icyitegererezo cyiza cya AlexNet, nicyitegererezo cyiza cya AlexNet.Ikarita yo gukora ibyiciro ikorwa mubyinjijwe byemejwe byubu buryo bune, kandi amakarita yubushyuhe atangwa mugushushanya amakarita yibikorwa hamwe namashusho yaturutse kuri 8 × 8 mm na 6 × 6 mm yo kwemeza22, 23.
R verisiyo 4.0.3 yakoreshejwe kubara imibare yose, kandi iyerekwa ryakozwe hifashishijwe isomero ryibikoresho bya ggplot2.
Twakusanyije amashusho 347 yimbere ya capillary plexus superficial apima 8 \ (\ inshuro \) mm 8 kuva kubantu 134.Imashini yatangaje imbaraga zerekana ibimenyetso ku gipimo cya 0 kugeza 10 ku mashusho yose (bivuze = 6.99 ± 2.29).Mu mashusho 347 yabonye, ​​imyaka iri hagati yo kwisuzumisha yari 58.7 ± 14,6, naho 39.2% ni iy'abarwayi b'abagabo.Mu mashusho yose, 30.8% ni abo muri Caucase, 32,6% bakomoka mu birabura, 30.8% bo muri Hisipanyika, 4% bo muri Aziya, na 1.7% bo mu yandi moko (Imbonerahamwe 1).).Ikwirakwizwa ryimyaka yabarwayi bafite OCTA ryatandukanye cyane bitewe nubwiza bwishusho (p <0.001).Ijanisha ry’amashusho meza cyane ku barwayi bakiri bato bafite hagati y’imyaka 18-45 yari 33.8% ugereranije na 12.2% y’amashusho make (Imbonerahamwe 1).Ikwirakwizwa rya retinopathie diabete naryo ryatandukanye cyane mubwiza bwibishusho (p <0.017).Mu mashusho yose yo mu rwego rwo hejuru, ijanisha ry’abarwayi bafite PDR ryari 18.8% ugereranije na 38.8% y’amashusho yose yo hasi (Imbonerahamwe 1).
Urutonde rwumuntu ku mashusho yose yerekanaga ko aringaniye kandi akomeye hagati yizerwa hagati yabantu basoma amashusho (Kappa iremereye ya Cohen = 0,79, 95% CI: 0.76-0.82), kandi nta ngingo yerekana amashusho aho abatanga amanota batandukanijwe nabarenga 1 (Ishusho. 2A)..Ububasha bwibimenyetso bufitanye isano cyane n amanota yintoki (Pearson progaramu yigihe cyo guhuza = 0.58, 95% CI 0.51–0.65, p <0.001), ariko amashusho menshi yagaragaye ko afite ubukana bwibimenyetso byinshi ariko amanota make yintoki (Ishusho .2B).
Mugihe cyamahugurwa yububiko bwa ResNet152 na AlexNet, igihombo cyambukiranya entropiya ku kwemeza no guhugura kigwa mu bihe birenga 50 (Ishusho 3B, C).Kwemeza neza mugihe cyamahugurwa yanyuma arenga 90% kubibazo byombi byo murwego rwo hejuru kandi bifite ireme.
Imikorere yakira umurongo werekana ko moderi ya ResNet152 irusha cyane imbaraga ibimenyetso byerekanwa na mashini murwego rwo hasi kandi rwiza rwo gukoresha (p <0.001).Moderi ya ResNet152 nayo iruta cyane imyubakire ya AlexNet (p = 0.005 na p = 0.014 kubibazo bito kandi bifite ireme).Icyitegererezo cyavuye kuri buri gikorwa cyashoboye kugera ku gaciro ka AUC ya 0,99 na 0,97, ibyo bikaba byiza cyane ugereranije nagaciro ka AUC gahwanye na 0.82 na 0.78 kubipimo byerekana imbaraga za mashini cyangwa 0.97 na 0.94 kuri AlexNet ..(Isanamu 3).Itandukaniro riri hagati ya ResNet na AUC mubimenyetso byimbaraga ni byinshi mugihe tumenye amashusho meza, byerekana inyungu zinyongera zo gukoresha ResNet muriki gikorwa.
Igishushanyo cyerekana ubushobozi bwa buri cyiciro cyigenga cyo gutanga amanota no kugereranya nimbaraga zerekana ibimenyetso byatangajwe na mashini.(A) Igiteranyo cy'amanota agomba gusuzumwa gikoreshwa mugukora umubare rusange w'amanota agomba gusuzumwa.Amashusho afite amanota yuzuye ya 4 yahawe inshingano zo hejuru, mugihe amashusho afite amanota rusange ya 1 cyangwa munsi yayo yahawe ubuziranenge..Umurongo utudomo utukura werekana uwabikoze asabwa kurenza urugero ashingiye ku mbaraga zerekana ibimenyetso (imbaraga z'ikimenyetso \ (\ ge \) 6).
Kwiga kwimura ResNet bitanga iterambere ryinshi mubiranga ubuziranenge bwibishusho haba murwego rwo hasi kandi rwiza rwo gukoresha ugereranije nurwego rwerekana ibimenyetso.(A) Igishushanyo mbonera cyubwubatsi cyateguwe mbere (i) ResNet152 na (ii) AlexNet yubatswe...
Nyuma yo guhindura imipaka ntarengwa, ibyemezo ntarengwa byerekana urugero rwa ResNet152 ni 95.3% kubibazo bito na 93.5% kubibazo byo hejuru (Imbonerahamwe 2).Umubare ntarengwa wo guhanura byerekana urugero rwa AlexNet ni 91.0% kubibazo bito na 90.1% kubibazo byo hejuru (Imbonerahamwe 2).Umubare ntarengwa wibimenyetso byerekana neza ni 76.1% kubibazo byo gukoresha ubuziranenge na 77.8% kubibazo byo murwego rwo hejuru.Dukurikije kappa ya Cohen (\ (\ kappa \)), amasezerano hagati ya moderi ya ResNet152 n'abayagereranya ni 0.90 ku rubanza rwo hasi na 0.81 ku rubanza rwo hejuru.Cohen's AlexNet kappa ni 0.82 na 0,71 kubibazo byo hasi kandi byujuje ubuziranenge.Cohen's signal strength kappa ni 0.52 na 0.27 kubibazo byo hasi kandi byiza byo gukoresha.
Kwemeza icyitegererezo cyo hejuru kandi cyiza cyo kumenyekanisha kuri 6 \ (\ x \) amashusho ya plaque ya mm 6 yerekana ubushobozi bwa moderi yatojwe kugirango amenye ubuziranenge bwibishusho mubice bitandukanye byerekana amashusho.Iyo ukoresheje 6 \ (\ x \) 6 mm ya plaque ntoya kugirango ube ufite amashusho meza, icyitegererezo cyo hasi cyari gifite AUC ya 0.83 (95% CI: 0.69–0.98) naho icyitegererezo cyiza cyari gifite AUC ya 0,85.(95% CI: 0.55–1.00) (Imbonerahamwe 2).
Igenzura ryerekanwa ryikarita yerekana ibyiciro byerekana ibikorwa byerekanaga ko imiyoboro yose yatojwe yakoresheje imiterere yibishusho mugihe cyo gushushanya (Ishusho 4A, B).Kuri 8 \ (\ inshuro \) mm 8 na 6 \ (\ inshuro \) 6 mm amashusho, amashusho ya ResNet akurikirana neza vasculature.Ikarita ya enterineti ya AlexNet nayo ikurikiza imiyoboro ya retina, ariko hamwe no gukemura neza.
Ikarita yo gutangiza ibyiciro bya moderi ya ResNet152 na AlexNet yerekana ibintu bijyanye nubwiza bwibishusho..Moderi ya LQ yatojwe kubipimo byujuje ubuziranenge, moderi ya HQ yatojwe kubipimo byiza.
Byerekanwe mbere ko ubwiza bwibishusho bushobora kugira ingaruka zikomeye kumubare uwo ariwo wose w'amashusho ya OCTA.Mubyongeyeho, kuba retinopathie ihari byongera ibihangano byamashusho7,26.Mubyukuri, mumibare yacu, ijyanye nubushakashatsi bwabanje, twabonye isano iri hagati yo kongera imyaka nuburemere bwindwara zifata umwijima no kwangirika kwubwiza bwibishusho (p <0.001, p = 0.017 kumyaka na DR uko bikurikirana; Imbonerahamwe 1) 27 . Kubwibyo, ni ngombwa gusuzuma ubuziranenge bwibishusho mbere yo gukora isesengura ryinshi ryamashusho ya OCTA.Ubushakashatsi bwinshi bwasesenguye amashusho ya OCTA bukoresha imashini yerekana ibimenyetso byerekana ubukana ntarengwa kugirango hirindwe amashusho make.Nubwo ubukana bwibimenyetso byagaragaye ko bugira ingaruka kumubare wibipimo bya OCTA, ubukana bwikimenyetso cyonyine ntibushobora kuba buhagije kugirango wirengagize amashusho hamwe nibishusho2,3,28,29.Kubwibyo, birakenewe guteza imbere uburyo bwizewe bwo kugenzura ubuziranenge bwibishusho.Kugirango tubigereho, turasuzuma imikorere yuburyo bwimbitse bwo kwiga burwanya imbaraga zerekana ibimenyetso byatangajwe na mashini.
Twateje imbere uburyo bwinshi bwo gusuzuma ubuziranenge bwibishusho kuko OCTA itandukanye ikoresha imanza zishobora kuba zifite ubuziranenge bwibishusho.Kurugero, amashusho agomba kuba yujuje ubuziranenge.Mubyongeyeho, ibipimo byihariye byerekana inyungu nabyo ni ngombwa.Kurugero, agace ka foveal avascular zone ntabwo gaterwa numuvurungano wikintu kitari hagati, ahubwo kigira ingaruka kubucucike bwimitsi.Mugihe ubushakashatsi bwacu bukomeje kwibanda kuburyo rusange kubijyanye nubwiza bwibishusho, butajyanye nibisabwa mu kizamini runaka, ariko bugamije gusimbuza byimazeyo imbaraga zerekana ibimenyetso byatangajwe na mashini, turizera guha abakoresha urwego runini rwo kugenzura kugirango nabo irashobora guhitamo ibipimo byihariye byinyungu kubakoresha.hitamo icyitegererezo gihuye nurwego ntarengwa rwibishusho bifatwa nkibyemewe.
Kubintu byujuje ubuziranenge kandi byujuje ubuziranenge, twerekana imikorere myiza yo guhuza-kubura imiyoboro yimbitse ihindagurika, hamwe na AUCs ya 0.97 na 0.99 hamwe nicyitegererezo cyo hasi.Turerekana kandi imikorere isumba iyindi yo kwiga byimbitse mugihe ugereranije nurwego rwibimenyetso rwatangajwe gusa nimashini.Gusimbuka guhuza bituma imiyoboro yimitsi yiga ibiranga murwego rwinshi rurambuye, ifata ibintu byiza byamashusho (urugero bitandukanye) kimwe nibiranga rusange (urugero: ishusho 30,31).Kubera ko ibihangano byerekana amashusho bigira ingaruka kumiterere yishusho birashoboka ko byamenyekanye neza murwego rwagutse, imiyoboro yimiterere yimiterere ifite imiyoboro yabuze irashobora kwerekana imikorere myiza kurenza iyidafite imirimo yo kugena ubuziranenge bwibishusho.
Mugihe twagerageje icyitegererezo cyacu kuri 6 \ (\ × 6mm) amashusho ya OCTA, twabonye igabanuka ryimikorere yibikorwa byombi byujuje ubuziranenge kandi buke (Ishusho 2), bitandukanye nubunini bwikitegererezo cyahuguwe mubyiciro.Ugereranije na moderi ya ResNet, moderi ya AlexNet ifite impanuka nini.Igikorwa cyiza cyane cya ResNet gishobora guterwa nubushobozi bwibisigisigi bisigaye byohereza amakuru kumunzani myinshi, bigatuma moderi irushaho gukomera mugushira amashusho yafashwe kumunzani itandukanye na / cyangwa gukuza.
Itandukaniro riri hagati ya 8 \ (\ × \) 8 mm amashusho na 6 \ (\ × \) 6 mm amashusho birashobora gutuma umuntu atondekanya nabi, harimo umubare munini ugereranije n’amashusho arimo uduce twa faval avasique, impinduka zigaragara, arcade yimitsi, na nta nervice optique ku ishusho 6 × 6 mm.Nubwo bimeze gurtyo, moderi yacu nziza ya ResNet yashoboye kugera kuri AUC ya 85% kumashusho ya 6 \ (\ x \) 6 mm, iboneza nticyigeze gitozwa, byerekana ko amakuru yubuziranenge bwibishusho yashizwe mumurongo wa neural ni byiza.kubunini bw'ishusho imwe cyangwa imashini iboneza hanze y'amahugurwa yayo (Imbonerahamwe 2).Icyizere, Ikarita yo gukora ya ResNet- na AlexNet isa na 8 \ (\ inshuro \) 8 mm 8 na 6 \ (\ inshuro \) 6 mm amashusho yashoboye kwerekana imiyoboro ya retina muribintu byombi, byerekana ko icyitegererezo gifite amakuru yingenzi.birakoreshwa muburyo bwo gutondekanya ubwoko bwombi bwamashusho ya OCTA (Ishusho 4).
Lauerman n'abandi.Isuzuma ryiza ryibishusho kumashusho ya OCTA naryo ryakozwe nkuburyo bwububiko bwa Inception, ubundi skip-ihuza convolutional neural net6,32 ukoresheje tekinoroji yimbitse.Bagabanije kandi ubushakashatsi ku mashusho ya capillary plexus superficial, ariko bakoresheje gusa amashusho mato mato ya 3 × 3 ya Optovue AngioVue, nubwo harimo abarwayi bafite indwara zitandukanye za chorioretinal.Akazi kacu gashingiye kumfatiro zabo, harimo moderi nyinshi kugirango dukemure ubuziranenge bwibishusho bitandukanye kandi twemeze ibisubizo kumashusho yubunini butandukanye.Turamenyesha kandi ibipimo bya AUC byerekana uburyo bwo kwiga imashini kandi tukongerera ibisobanuro bitangaje (90%) 6 kubintu byombi bifite ubuziranenge (96%) hamwe nubwiza bwo hejuru (95.7% )6.
Aya mahugurwa afite aho agarukira.Ubwa mbere, amashusho yabonetse afite imashini imwe gusa ya OCTA, harimo amashusho gusa ya capillary plexus yimbere kuri 8 \ (\ inshuro \) 8 mm 8 na 6 \ (\ inshuro \) mm 6.Impamvu yo gukuramo amashusho mubice byimbitse nuko ibihangano bya projection bishobora gutuma isuzuma ryintoki ryamashusho rigoye kandi birashoboka ko ridahuye.Byongeye kandi, amashusho yabonetse gusa kubarwayi ba diyabete, kuri bo OCTA igaragara nkigikoresho cyingenzi cyo gusuzuma no gutangaza 33,34.Nubwo twashoboye kugerageza icyitegererezo cyacu kumashusho yubunini butandukanye kugirango tumenye neza ko ibisubizo byakomeye, ntitwashoboye kumenya imibare ikwiye yaturutse mubigo bitandukanye, byagabanije gusuzuma isuzuma rusange ryikitegererezo.Nubwo amashusho yakuwe mu kigo kimwe gusa, yabonetse ku barwayi bo mu moko atandukanye ndetse n’amoko, akaba ari imbaraga zidasanzwe z’ubushakashatsi bwacu.Dushizemo ubudasa mubikorwa byamahugurwa yacu, turizera ko ibisubizo byacu bizashyirwa mubikorwa muburyo bwagutse, kandi ko tuzirinda gushyiramo kubogama kwamoko mubyitegererezo duhugura.
Ubushakashatsi bwacu bwerekana ko imiyoboro-isimbuka imiyoboro ihuza imiyoboro ishobora gutozwa kugera ku mikorere ihanitse mu kumenya ubwiza bw’ishusho ya OCTA.Dutanze ubu buryo nkibikoresho byo gukora ubushakashatsi.Kuberako ibipimo bitandukanye bishobora kuba bifite ubuziranenge bwibishusho bisabwa, icyitegererezo cyo kugenzura ubuziranenge gishobora gutezwa imbere kuri buri metero ukoresheje imiterere yashizweho hano.
Ubushakashatsi bw'ejo hazaza bugomba kuba bukubiyemo amashusho yubunini butandukanye kuva mubwimbike butandukanye hamwe nimashini zitandukanye za OCTA kugirango ubone uburyo bwimbitse bwo kwiga ishusho yubuziranenge bushobora guhurizwa hamwe kuri OCTA hamwe na protocole yerekana amashusho.Ubushakashatsi bugezweho kandi bushingiye ku buryo bwimbitse bwo kwiga busaba isuzuma ryabantu no gusuzuma amashusho, bishobora kuba imbaraga nyinshi kandi bigatwara igihe kinini kuri datasets.Hasigaye kurebwa niba uburyo bwimbitse bwokwiga butagenzuwe bushobora gutandukanya bihagije amashusho yujuje ubuziranenge namashusho meza.
Mugihe ikoranabuhanga rya OCTA rikomeje kugenda ryiyongera kandi umuvuduko wo gusikana wiyongera, umubare wibikoresho byamashusho nibishusho bibi bishobora kugabanuka.Gutezimbere muri software, nkibintu biherutse gutangizwa bya projection artifact yo gukuraho, birashobora kandi kugabanya izo mbogamizi.Nubwo bimeze bityo ariko, ibibazo byinshi bikomeza kuba amashusho y’abarwayi bafite ikibazo cyo gukosorwa nabi cyangwa itangazamakuru ridahinduka cyane bivamo ibihangano.Mugihe OCTA ikoreshwa cyane mubigeragezo byamavuriro, birakenewe ko harebwa neza kugirango hamenyekane umurongo ngenderwaho wurwego rwemewe rwo gushushanya amashusho.Gukoresha uburyo bwimbitse bwo kwiga kumashusho ya OCTA bufite amasezerano akomeye kandi ubushakashatsi buracyakenewe muriki gice kugirango utezimbere uburyo bukomeye bwo kugenzura ubuziranenge bwibishusho.
Kode yakoreshejwe mubushakashatsi burimo iraboneka mububiko bwa octa-qc, https://github.com/rahuldhodapkar/octa-qc.Imibare yatanzwe kandi / cyangwa yasesenguwe mugihe cyubu ubushakashatsi iraboneka kubanditsi babisabwe neza.
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